N,N-Dimethylaminoethyl chloride hydrochloride → N-[4-chloro-3-(2-dimethylamino-ethoxy)-phenyl]-acetamide

HRID 330786Notes

Reaction equation

HRID 330786 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[OH:12].Cl.[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17]Cl>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[O:12][CH2:17][CH2:16][N:15]([CH3:19])[CH3:14]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 14122483N-(4-Chloro-3-hydroxyphenyl)acetamide

Product 1

HCID 86684781N-[4-chloro-3-(2-dimethylamino-ethoxy)-phenyl]-acetamideYield 80%

Procedure

The compound 24a was prepared starting from 17a and 2-dimethylamino ethyl chloride hydrochloride, following the general procedure H, as given in Example 9, in 80% yield.

Sources & evidence

ORD record
ord-d9c152a8d2914cc79373a2b96b41a6d5
Source dataset
uspto-grants-2014_11
Patent number
US08877752B2

Reaction notes

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