反应详情

7a-(3-Benzyl-5-isoxazolyl)-hexahydro-1H-pyrrolizine (407 mg, 1.52 mmol, from step 15c) was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the precipitate was recrystallized from MeOH and dried to afford the title compound as white needles: mp 126°-127° C.; 1H NMR D2O, 300 MHz) δ2.17-2.36 (m, 6H), 2.53-2.62 (m, 2H), 3.28-3.36 (m, 2H), 3.67-3.75 (m, 2H), 4.08 (s, 2H), 6.57 (s, 1H), 7.34-7.45 (m, 5H); MS (CI/NH3) m/z: 269 (M+H)+; Anal. Calcd for C17H20N2O.HCl: C, 66.99; H, 6.94; N, 9.19. Found: C, 66.99; H, 6.87; N, 9.09.

1. customThe solvent was removed
2. customthe precipitate was recrystallized from MeOH
3. customdried