Hydrochloric Acid → HCID 46846722, compound

HRID 330802Notes

Reaction equation

HRID 330802 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:17]=[N:18][C:19]([C:22]3[CH:23]=[C:24]([CH:40]=[CH:41][CH:42]=3)[CH2:25][N:26]3[C:30]4[CH:31]=[C:32]([C:35]([F:38])([F:37])[F:36])[CH:33]=[CH:34][C:29]=4[S:28][C:27]3=[O:39])=[N:20][CH:21]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][C:16]2[CH:17]=[N:18][C:19]([C:22]3[CH:23]=[C:24]([CH:40]=[CH:41][CH:42]=3)[CH2:25][N:26]3[C:30]4[CH:31]=[C:32]([C:35]([F:36])([F:38])[F:37])[CH:33]=[CH:34][C:29]=4[S:28][C:27]3=[O:39])=[N:20][CH:21]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46846630HCID 46846630, compound

Product 1

HCID 46846722HCID 46846722, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

424 mg (0.64 mmol) of 3-{3-[5-(1-tert-butoxycarbonylpiperidin-4-yl-methoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one is dissolved in 20 ml of dioxane, and 6 ml of 4N HCl in dioxane are added. The mixture is stirred at room temperature for 24 h. A viscous precipitate forms in the process, which is filtered off with suction and stirred with isopropanol.

Workup

  1. filtrationA viscous precipitate forms in the process, which is filtered off with suction
  2. stirringstirred with isopropanol

Sources & evidence

ORD record
ord-72af8d8b58344a33b57e2ec1935b028b
Source dataset
uspto-grants-2014_11
Patent number
US08877751B2

Reaction notes

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