反应详情

To 2.00 g (8.35 mmol) 2-chloro-4-iodopyridine in 15 mL ethanol are added 3.4 mL (9.2 mmol) sodium ethoxide and stirred at reflux for 12 h. The solvent is evaporated in vacuo and the residue is partitioned between water and DCM. The organic layer is dried over sodium sulphate and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel; DCM/MeOH gradient 100/0→96/4).

1. temperatureat reflux for 12 h
2. customThe solvent is evaporated in vacuo
3. customthe residue is partitioned between water and DCM
4. dry with materialThe organic layer is dried over sodium sulphate
5. customthe solvent is removed in vacuo
6. customThe crude product is purified by column chromatography (silica gel; DCM/MeOH gradient 100/0→96/4)