HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Propanol → 4-Iodo-2-propoxy-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Propanol | HCID 1031 | — |
| Reactant | 2-Chloro-4-iodopyridine | HCID 1516511 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Iodo-2-propoxy-pyridine | HCID 66614410 | — |
Reaction Steps
0.58 g (25 mmol) sodium are carefully added to 40 mL n-propanol in several portions. The mixture is stirred for 45 min. After that time, 6.0 g (25 mmol) 2-chloro-4-iodo-pyridine are slowly added to the mixture. The mixture is stirred at reflux for 3 h. Subsequently, water is added and the solvent is removed in vacuo. The residue is taken up in 20 mL DMF/MeOH, filtrated and the filtrate is purified by RP-HPLC (MeOH/H2O/NH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877754B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f3c3eb2351a14199ab662644accaefa1 |
| Source note | uspto-grants-2014_11 |