反应详情

0.58 g (25 mmol) sodium are carefully added to 40 mL n-propanol in several portions. The mixture is stirred for 45 min. After that time, 6.0 g (25 mmol) 2-chloro-4-iodo-pyridine are slowly added to the mixture. The mixture is stirred at reflux for 3 h. Subsequently, water is added and the solvent is removed in vacuo. The residue is taken up in 20 mL DMF/MeOH, filtrated and the filtrate is purified by RP-HPLC (MeOH/H2O/NH3).

1. stirringThe mixture is stirred
2. temperatureat reflux for 3 h
3. customthe solvent is removed in vacuo
4. filtrationfiltrated
5. customthe filtrate is purified by RP-HPLC (MeOH/H2O/NH3)