HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Iodo-N-propyl-2-pyridone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Bromopropane | HCID 7840 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Iodo-1,2-dihydropyridin-2-one | HCID 20582535 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Iodo-N-propyl-2-pyridone | HCID 66634966 | — |
Reaction Steps
2.00 g (9.05 mmol) 4-iodo-2-pyridone (XXII.1) are added to 1.00 mL (10.9 mmol) 1-bromopropane and 3.13 g (22.6 mmol) K2CO3 in 10 mL DMF. The mixture is stirred at rt over night. After that time, water is added and the mixture is extracted with EtOAc. The organic layer is washed with aq. NaHCO3 solution, dried over sodium sulphate and the solvent is removed in vacuo. The residue is purified by RP-HPLC (water+0.15% FA, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877754B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-273df454719b460babdd2d064a4b7bfa |
| Source note | uspto-grants-2014_11 |