反应详情

2.00 g (9.05 mmol) 4-iodo-2-pyridone (XXII.1) are added to 1.00 mL (10.9 mmol) 1-bromopropane and 3.13 g (22.6 mmol) K2CO3 in 10 mL DMF. The mixture is stirred at rt over night. After that time, water is added and the mixture is extracted with EtOAc. The organic layer is washed with aq. NaHCO3 solution, dried over sodium sulphate and the solvent is removed in vacuo. The residue is purified by RP-HPLC (water+0.15% FA, MeOH).

1. extractionthe mixture is extracted with EtOAc
2. washThe organic layer is washed with aq. NaHCO3 solution
3. dry with materialdried over sodium sulphate
4. customthe solvent is removed in vacuo
5. customThe residue is purified by RP-HPLC (water+0.15% FA, MeOH)