HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 3-[4-(4-Ethoxy-phenylethynyl)-phenyl]-N-methyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-[4-(4-Ethoxy-phenylethynyl)-phenyl]-propionic acid | HCID 66691426 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[4-(4-Ethoxy-phenylethynyl)-phenyl]-N-methyl-propionamide | HCID 68181112 | — |
Reaction Steps
To 100 mg (0.34 mmol) 3-[4-(4-ethoxy-phenylethynyl)-phenyl]-propionic acid (XIV.1) in 5 mL DMF are added 0.12 mL (0.85 mmol) TEA and 0.12 g (0.37 mmol) TBTU and the mixture is stirred for 5 min at rt. After that time, 21 mg (0.68 mmol) methylamine are added and the mixture is stirred at rt for 2 h. Subsequently saturated potassium hydrogencarbonate solution and water are added. The precipitate is filtered, washed with water and dried at 45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877754B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d73f6aeda0044a628dec0f1921554c86 |
| Source note | uspto-grants-2014_11 |