反应详情

To 100 mg (0.34 mmol) 3-[4-(4-ethoxy-phenylethynyl)-phenyl]-propionic acid (XIV.1) in 5 mL DMF are added 0.12 mL (0.85 mmol) TEA and 0.12 g (0.37 mmol) TBTU and the mixture is stirred for 5 min at rt. After that time, 21 mg (0.68 mmol) methylamine are added and the mixture is stirred at rt for 2 h. Subsequently saturated potassium hydrogencarbonate solution and water are added. The precipitate is filtered, washed with water and dried at 45° C.

1. stirringthe mixture is stirred at rt for 2 h
2. filtrationThe precipitate is filtered
3. washwashed with water
4. customdried at 45° C.