Piperazine → HCID 59606520, compound

HRID 330876Notes

Reaction equation

HRID 330876 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>C(O)C>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 951233,4,6-Trichloropyridazine

Product 1

HCID 59606520HCID 59606520, compoundYield 61.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

18 g 3,4,6-trichloro-pyridazine and 34 g piperazine are suspended in 100 ml of ethanol and stirred for 30 minutes at ambient temperature. The precipitated solid is suction filtered. 500 ml of water are added to the mother liquor and the precipitated product is suction filtered. 14 g product are obtained as a solid. M.p=111-115° C.

Workup

  1. filtrationfiltered
  2. addition500 ml of water are added to the mother liquor
  3. filtrationfiltered

Sources & evidence

ORD record
ord-48a7fd84c4a5461b816d330589350376
Source dataset
uspto-grants-2014_11
Patent number
US08877758B2

Reaction notes

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