Ammonia → HCID 45078476, compound

HRID 330882Notes

Reaction equation

HRID 330882 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[NH:10][C:9](=O)[N:8]([CH3:13])[C:7]=2[CH:6]=[CH:5][CH:4]=1.N.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:9]1[N:8]([CH3:13])[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[N:10]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 24813Phosphorus oxychlorideHCID 59606518HCID 59606518, compound

Product 1

HCID 45078476HCID 45078476, compound

Procedure

3.7 g 4-methoxy-1-methyl-1,3-dihydrobenzimidazol-2-one are suspended in 15 ml phosphorus oxychloride. The reaction mixture is stirred for 3 hours at reflux temperature, slowly combined with ice water and made alkaline with conc. ammonia. The precipitated product is suction filtered. 3.6 g product are obtained as a solid. M.p=118-119° C.

Workup

  1. temperatureat reflux temperature
  2. filtrationfiltered

Sources & evidence

ORD record
ord-293bb8cfc3af4680add50ed0e8a58f31
Source dataset
uspto-grants-2014_11
Patent number
US08877758B2

Reaction notes

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