反应详情

A mixture of tert-butyl {trans-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]cyclopentyl}methylcarbamate 115 (0.19 g, 0.53 mmol) was treated with hydrazine hydrate (0.03 g, 0.60 mmol). The mixture was stirred at room temperature for 2 hours. The solid was filtered off and the filtrate was concentrated in vacuo. The residue was diluted with DCM, and the insoluble solid was filtered off. The filtrate was concentrated in vacuo to give an oil which was purified by chromatography to give 116 (0.09 g, 44% over 2 steps) as a light yellow oil.

1. filtrationThe solid was filtered off
2. concentrationthe filtrate was concentrated in vacuo
3. additionThe residue was diluted with DCM
4. filtrationthe insoluble solid was filtered off
5. concentrationThe filtrate was concentrated in vacuo
6. customto give an oil which
7. customwas purified by chromatography