反应详情

A mixture of 4-bromo-1H-pyrrolo[2,3-b]pyridine (2 g, 10.15 mmol) in diethyl ether (160 mL) was cooled to 0° C. mCPBA (3.64 g, 16.24 mmol) was added to the mixture at 0° C. After stirring for 20 min at this temperature, the mixture was allowed to warm to RT and stirred for 3 hours. The formed precipitate was filtered and washed with cold ether to give the title compound (1.978 g). LCMS (A): m/z (M+H)+ 213/215, C7H5BrN2O requires 212/214 (acidic).

1. additionwas added to the mixture at 0° C
2. stirringstirred for 3 hours
3. filtrationThe formed precipitate was filtered
4. washwashed with cold ether