反应详情

To a stirred solution of tert-butyl 4-(N-(3-(5-fluoro-1-methylindolin-6-yl)-1-isopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)sulfamoyl)piperidine-1-carboxylate (D38) (442 mg, 0.773 mmol) in DCM (5 mL) at RT was added 4M HCl in 1,4-dioxane (1.933 mL, 7.73 mmol). The reaction mixture stirred at RT overnight. The reaction mixture was concentrated in vacuo to afford the title compound (500 mg). The material was used in next step without further purification. LCMS (A): m/z [(M−HCl)+H]+ 472, C24H30FN5O2S.HCl requires 507 (acidic).

1. concentrationThe reaction mixture was concentrated in vacuo