Quinoline → HCID 933997, compound

Participants

Reaction Conditions

Reaction Steps

6-Bromo-5-methoxy-1,2-dimethyl-1H-indole-3-carboxylic acid (1.02 g, 3.42 mmol) was separated into two round bottom flasks (each with 500 mg of material), followed by the addition of quinoline (2 mL) in each flask. The reaction mixture was heated at 200° C. for 4 hours and was cooled to RT. The two reaction mixture was combined and loaded directly on a silica gel column, eluting with a gradient of 0-20% ethyl acetate in cyclohexane, to give title compound (435 mg). LCMS (A): m/z (M+H)+ 254/256, C11H12BrNO requires 253/255 (acidic).

Provenance & Evidence