反应详情

In a manner analogous to that described in Example 2c), the ammonolysis of (R)-5-[5-(5-chloro-benzo oxazol-2-yl)-2,4-difluoro-phenyl]-6,6-difluoro-5,7,7-trimethyl-[1,4]oxazepan-3-thione (35 mg, 74 μmol) with ammonia (7M in methanol; 0.73 ml) and tert-butylhydroperoxide (70% in water; 71 μl) yielded the title compound (14 mg, 43% yield). MS (ISP): m/z=456.3 [M+H]+ and 458.2 [M+2+H]+.