反应详情

In a manner analogous to that described in Example 2c), the ammonolysis of (R)-5-[5-(5,6-difluoro-benzo oxazol-2-yl)-2,4-difluoro-phenyl]-6,6-difluoro-5,7,7-trimethyl-[1,4]oxazepan-3-thione (83 mg, 175 μmol) with ammonia (7M in methanol; 1.72 ml) and tert-butylhydroperoxide (70% in water; 183 μl) yielded the title compound (19 mg, 24% yield). MS (ISP): m/z=458.2 [M+H]+.