Hydrochloric Acid → 1-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

HRID 331218Notes

Reaction equation

HRID 331218 reaction equation
FC1C=CC=C2C=1CCC2=O.[F:12][C:13]1([N:28]2[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[NH:30][C:29]2=[O:37])[CH2:18][CH2:17][N:16]([CH:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21][CH2:20]2)[CH2:15][CH2:14]1.[ClH:38].Cl.C(OCC)(=O)C>>[ClH:38].[F:12][C:13]1([N:28]2[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[NH:30][C:29]2=[O:37])[CH2:18][CH2:17][N:16]([CH:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21][CH2:20]2)[CH2:15][CH2:14]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 121749864-Fluoro-1-indanoneHCID 21866389Hydrogen chloride-ethyl acetateHCID 687013111-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one

Product 1

HCID 687013101-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Procedure

In the same manner as in Example 1 and using 4-fluoro-1-indanone, 1-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one was synthesized, which was then converted to hydrochloride with 4N hydrochloric acid-ethyl acetate solution to give the title compound as a brown solid.

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-0077fe4cb168461a9abbb4d6f050a39b
Source dataset
uspto-grants-2014_11
Patent number
US08877779B2

Reaction notes

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