Hydrochloric Acid → HCID 68706886, compound

HRID 331220Notes

Reaction equation

HRID 331220 reaction equation
CC1(N2C3C=CC=CC=3NC2=O)CCN(C2C3C(=CC=CC=3)CC2)CC1.[CH3:27][C:28]1([N:43]2[C:47]3[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=3[N:45]([CH2:52][C:53]([NH:55][CH3:56])=[O:54])[C:44]2=[O:57])[CH2:33][CH2:32][N:31]([CH:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:36][CH2:35]2)[CH2:30][CH2:29]1.[ClH:58].Cl.C(OCC)(=O)C>>[ClH:58].[CH3:27][C:28]1([N:43]2[C:47]3[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=3[N:45]([CH2:52][C:53]([NH:55][CH3:56])=[O:54])[C:44]2=[O:57])[CH2:33][CH2:32][N:31]([CH:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:36][CH2:35]2)[CH2:30][CH2:29]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 21866389Hydrogen chloride-ethyl acetateHCID 68703904HCID 68703904, compoundHCID 68706246HCID 68706246, compound

Product 1

HCID 68706886HCID 68706886, compound

Procedure

In the same manner as in Example 2 and using 1-(4-methyl-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one, 2-{3-(4-methyl-1-indan-1-ylpiperidin-4-yl)-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide was synthesized, which was then converted to hydrochloride with 4N hydrochloric acid-ethyl acetate solution to give the title compound as a brown solid.

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-0533bff9e3e54dcdaed40963ed8bfc15
Source dataset
uspto-grants-2014_11
Patent number
US08877779B2

Reaction notes

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