Hydrochloric Acid → HCID 68702139, compound

HRID 331221Notes

Reaction equation

HRID 331221 reaction equation
CC1N(C2C3C(=CC=CC=3)CC2)CCC(N2C3C=CC=CC=3NC2=O)C1.[CH3:27][CH:28]1[N:33]([CH:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:36][CH2:35]2)[CH2:32][CH2:31][CH:30]([N:43]2[C:47]3[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=3[N:45]([CH2:52][C:53]([NH:55][CH3:56])=[O:54])[C:44]2=[O:57])[CH2:29]1.[ClH:58].Cl.C(OCC)(=O)C>>[ClH:58].[CH3:27][CH:28]1[N:33]([CH:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:36][CH2:35]2)[CH2:32][CH2:31][CH:30]([N:43]2[C:47]3[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=3[N:45]([CH2:52][C:53]([NH:55][CH3:56])=[O:54])[C:44]2=[O:57])[CH2:29]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 21866389Hydrogen chloride-ethyl acetateHCID 68701868HCID 68701868, compoundHCID 68702140HCID 68702140, compound

Product 1

HCID 68702139HCID 68702139, compound

Procedure

In the same manner as in Example 2 and using 1-(6-methyl-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one, 2-{3-(6-methyl-1-indan-1-ylpiperidin-4-yl)-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide was synthesized, which was then converted to hydrochloride with 4N hydrochloric acid-ethyl acetate solution to give the title compound as a brown solid.

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-8dbf46c30c8f460ea20dc046265de6ce
Source dataset
uspto-grants-2014_11
Patent number
US08877779B2

Reaction notes

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