Hydrochloric Acid → HCID 68705368, compound

HRID 331222Notes

Reaction equation

HRID 331222 reaction equation
CC1C=CC=C2C=1C(N1CCC(N3C4C=CC=CC=4NC3=O)CC1)CC2.[CH3:27][C:28]1[CH:29]=[CH:30][CH:31]=[C:32]2[C:36]=1[CH:35]([N:37]1[CH2:42][CH2:41][CH:40]([N:43]3[C:47]4[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=4[N:45]([CH2:52][C:53]([NH:55][CH3:56])=[O:54])[C:44]3=[O:57])[CH2:39][CH2:38]1)[CH2:34][CH2:33]2.[ClH:58].Cl.C(OCC)(=O)C>>[ClH:58].[CH3:27][C:28]1[CH:29]=[CH:30][CH:31]=[C:32]2[C:36]=1[CH:35]([N:37]1[CH2:38][CH2:39][CH:40]([N:43]3[C:47]4[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=4[N:45]([CH2:52][C:53]([NH:55][CH3:56])=[O:54])[C:44]3=[O:57])[CH2:41][CH2:42]1)[CH2:34][CH2:33]2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 21866389Hydrogen chloride-ethyl acetateHCID 59322956HCID 59322956, compoundHCID 59323005HCID 59323005, compound

Product 1

HCID 68705368HCID 68705368, compound

Procedure

In the same manner as in Example 2 and using 1-(7-methyl-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one, 2-{3-(7-methyl-1-indan-1-ylpiperidin-4-yl)-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide was synthesized, which was then converted to hydrochloride with 4N hydrochloric acid-ethyl acetate solution to give the title compound as a brown solid.

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-ce8327feced04e26a71bb2e8d302726f
Source dataset
uspto-grants-2014_11
Patent number
US08877779B2

Reaction notes

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