Dichloromethane → HCID 86641630, compound

HRID 331232Notes

Reaction equation

HRID 331232 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([CH2:11][OH:12])[CH2:3][CH2:2]1.C(Cl)Cl.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>O>[CH3:23][S:24]([O:12][CH2:11][CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[O:1][CH2:2][CH2:3]1)(=[O:26])=[O:25]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 1361645533313-82-5

Product 1

HCID 86641630HCID 86641630, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To chroman-4-ylmethanol (15.0 g), methylene chloride (80 ml) and triethylamine (12.9 ml) was added dropwise methanesulfonyl chloride (6.85 ml) under ice-cooling, and the mixture was stirred for 2 hr. The reaction mixture was poured into water, and the mixture was extracted with methylene chloride. The extract was washed with water and saturated brine, dried over magnesium sulfate, and concentrated to give chroman-4-ylmethyl methanesulfonate.

Workup

  1. temperaturecooling
  2. extractionthe mixture was extracted with methylene chloride
  3. washThe extract was washed with water and saturated brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-832e45f83315411da72f234683cf076e
Source dataset
uspto-grants-2014_11
Patent number
US08877779B2

Reaction notes

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