Acetyl chloride → 1-(2-Bromo-4-methoxyphenyl)ethan-1-one

HRID 331254Notes

Reaction equation

HRID 331254 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Al+3].[Cl-].[Cl-].[Cl-].[Br:9][C:10]1[CH:11]=[C:12]([O:16][CH3:17])[CH:13]=[CH:14][CH:15]=1>C(=S)=S>[Br:9][C:10]1[CH:11]=[C:12]([O:16][CH3:17])[CH:13]=[CH:14][C:15]=1[C:1](=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 169713-BromoanisoleHCID 6451240Aluminum(III) Chloride

Product 1

HCID 106570061-(2-Bromo-4-methoxyphenyl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 6348Carbon DisulfideSolvent2×

Procedure

Acetyl chloride (1 to 1.2 eq) and AlCl3 (1 to 1.2 eq) are mixed with carbon disulfide, 3-bromoanisole dissolved in carbon disulfide is added thereto. The resulting mixture is stirred for 10 to 16 h at room temperature, to obtain 1-(2-bromo-4-methoxyphenyl)ethanone of formula 14.

Workup

  1. additionis added

Sources & evidence

ORD record
ord-9bf2e95985fb4b7081ca472bdd9182b0
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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