3-(4-(Trifluoromethyl)phenyl)-2,3-dihydro-6-hydroxyinden-1-one → 1-(4-(Trifluoromethyl)phenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetate

HRID 331280Notes

Reaction equation

HRID 331280 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[C:11](=[O:19])[CH2:10]2)=[CH:5][CH:4]=1.[OH:22][C:23]1C=C2C(C(C3C=CC=CC=3)CC2=O)=C[CH:24]=1>>[C:23]([O:18][C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][CH:15]=1)[CH:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:20])([F:21])[F:1])=[CH:8][CH:7]=1)[CH2:10][C:11]2=[O:19])(=[O:22])[CH3:24]

Participants

3

Reactant 2

HCID 703074073-(4-(Trifluoromethyl)phenyl)-2,3-dihydro-6-hydroxyinden-1-oneHCID 703075012,3-Dihydro-6-hydroxy-3-phenylinden-1-one

Product 1

HCID 703127951-(4-(Trifluoromethyl)phenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetateYield 99%

Procedure

The procedure of Step 3 of Example 1 was repeated except for using 3-(4-(trifluoromethyl)phenyl)-2,3-dihydro-6-hydroxyinden-1-one obtained in Step 2 as a starting material instead of 2,3-dihydro-6-hydroxy-3-phenylinden-1-one and being stirred for 3 h to obtain the title compound (99%).

Sources & evidence

ORD record
ord-9cb761cc100140a9930418fe96fdcaae
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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