2-Bromo-1-oxo-3-phenyl-1H-inden-6-yl acetate → 2-Bromo-3-(3,5-difluorophenyl)-6-hydroxy-1H-inden-1-one

HRID 331287Notes

Reaction equation

HRID 331287 reaction equation
C([O:4][C:5]1[CH:13]=[C:12]2[C:8]([C:9]([C:16]3[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=3)=[C:10]([Br:15])[C:11]2=[O:14])=[CH:7][CH:6]=1)(=O)C.C(OC1C=C2C(C(C3C=CC=CC=3)=C(Br)C2=O)=CC=1)(=O)C>>[Br:15][C:10]1[C:11](=[O:14])[C:12]2[C:8]([C:9]=1[C:16]1[CH:17]=[C:18]([F:23])[CH:19]=[C:20]([F:22])[CH:21]=1)=[CH:7][CH:6]=[C:5]([OH:4])[CH:13]=2

Participants

3

Reactant 2

HCID 703132412-Bromo-1-oxo-3-phenyl-1H-inden-6-yl acetateHCID 703144442-Bromo-3-(3,5-difluorophenyl)-1-oxo-1H-inden-6-yl acetate

Product 1

HCID 703160432-Bromo-3-(3,5-difluorophenyl)-6-hydroxy-1H-inden-1-oneYield 64%

Procedure

The procedure of Step 5 of Example 1 was repeated except for using 2-bromo-3-(3,5-difluorophenyl)-1-oxo-1H-inden-6-yl acetate obtained in Step 4 as a starting material instead of 2-bromo-1-oxo-3-phenyl-1H-inden-6-yl acetate and being stirred for 2.5 h to obtain the title compound (64%).

Sources & evidence

ORD record
ord-c12a60aa7b844d70ac8478e2964908b9
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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