6-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one → 3-(4-Chlorophenyl)-2-(3,4-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one hydrochloride salt

HRID 331302Notes

Reaction equation

HRID 331302 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][N:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH2:22][CH2:21]4)=[CH:14][CH:15]=3)[C:10](=[O:30])[C:9]=2[C:31]2[CH:36]=[CH:35][C:34]([F:37])=[C:33]([F:38])[CH:32]=2)=[CH:4][CH:3]=1.O1CCN(CCOC2C=C3C(C(C4C=CC=CC=4)=C(C4C=NC=CC=4)C3=O)=CC=2)CC1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][N:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH2:22][CH2:21]4)=[CH:14][CH:15]=3)[C:10](=[O:30])[C:9]=2[C:31]2[CH:36]=[CH:35][C:34]([F:37])=[C:33]([F:38])[CH:32]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 509405096-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-oneHCID 510018323-(4-Chlorophenyl)-2-(3,4-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one

Product 1

HCID 703105813-(4-Chlorophenyl)-2-(3,4-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one hydrochloride salt

Procedure

The procedure of Step 8 of Example 1 was repeated except for using 3-(4-chlorophenyl)-2-(3,4-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one obtained in Step 2 as a starting material instead of 6-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one to give the title compound in quantitative yield.

Sources & evidence

ORD record
ord-81c652fba7ef407fa6c7557892aada9f
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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