HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-2-(piperazin-1-yl)-1,3-benzothiazole → [4-(6-Chloro-benzothiazol-2-yl)-piperazin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-2-(piperazin-1-yl)-1,3-benzothiazole | HCID 2746595 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Product | [4-(6-Chloro-benzothiazol-2-yl)-piperazin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone | HCID 11648903 | — |
Reaction Steps
Prepared in analogy to example 1.1 b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 6-chloro-2-piperazin-1-yl-benzothiazole. The crude material was purified by chromatography (SiO2, CH2Cl2/MeOH=95/5) to yield the title compound as a yellowish solid. MS (m/e): 552.3 (M+CH3COOH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429585B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-5268c11bda30498b84116ce689da3065 |
| Source note | uspto-grants-2008_09 |