Hydrochloric Acid → 2-(Piperazin-1-yl)benzo[d]oxazole hydrochloride

HRID 33141Notes

Reaction equation

HRID 33141 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[O:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[N:11]1([C:14]2[O:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 40144297tert-Butyl 4-(1,3-benzoxazol-2-yl)piperazine-1-carboxylate

Product 1

HCID 665702142-(Piperazin-1-yl)benzo[d]oxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10.8 mmol of 4-benzoxazol-2-yl-piperazine-1-carboxylic acid tert.-butyl ester were treated with 30 ml of a dioxane, saturated with gaseous hydrochloric acid. The heterogenous mixture was stirred at room temperature for 1 hour, before evaporation of the solvent. This yielded the title compound as a colorless solid.

Sources & evidence

ORD record
ord-e7c2240539a344748471d5aeb8b8f0b0
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

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