Tetrahydropyran-4-ylacetic acid → HCID 178520324, compound

HRID 331410Notes

Reaction equation

HRID 331410 reaction equation
Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[O:27]1[CH2:32][CH2:31][CH:30]([CH2:33][C:34](O)=[O:35])[CH2:29][CH2:28]1>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:34](=[O:35])[CH2:33][CH:30]5[CH2:31][CH2:32][O:27][CH2:28][CH2:29]5)[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 2773575Tetrahydropyran-4-ylacetic acidHCID 178478710HCID 178478710, compound2×

Product 1

HCID 178520324HCID 178520324, compound

Procedure

The title compound, off-white solid (67 mg, 79%), MS (ISP) m/z=455.5 [(M+H)+], mp 191° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (75 mg, 0.19 mmol) and tetrahydropyran-4-yl-acetic acid.

Sources & evidence

ORD record
ord-32a60a9995be420883182f0a923a6882
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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