Tetrahydropyran-4-ylacetic acid → HCID 178520324, compound

Participants

Reaction Steps

The title compound, off-white solid (67 mg, 79%), MS (ISP) m/z=455.5 [(M+H)+], mp 191° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (75 mg, 0.19 mmol) and tetrahydropyran-4-yl-acetic acid.

Provenance & Evidence