2-Methanesulfonylacetic acid → HCID 178504898, compound

HRID 331413Notes

Reaction equation

HRID 331413 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)[CH:5]=[CH:4]1.[CH3:27][S:28]([CH2:31][C:32](O)=[O:33])(=[O:30])=[O:29]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:32](=[O:33])[CH2:31][S:28]([CH3:27])(=[O:30])=[O:29])[CH2:24][CH2:25]2)[CH:5]=[CH:4]1

Participants

3

Reactant 2

HCID 37328412-Methanesulfonylacetic acidHCID 178478712HCID 178478712, compound2×

Product 1

HCID 178504898HCID 178504898, compound

Procedure

The title compound, off-white solid (77 mg, 60%), MS (ISP) m/z=447.4 [(M+H)+], mp 201° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl-amine dihydrochloride (intermediate A) (115 mg, 0.29 mmol) and 2-methanesulfonyl-acetic acid.

Sources & evidence

ORD record
ord-f7efd7838a6d4369ababdea519f701f1
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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