1-Hydroxycyclobutanecarboxylic acid → HCID 178523606, compound

HRID 331440Notes

Reaction equation

HRID 331440 reaction equation
Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[OH:27][C:28]1([C:32](O)=[O:33])[CH2:31][CH2:30][CH2:29]1>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:32]([C:28]5([OH:27])[CH2:31][CH2:30][CH2:29]5)=[O:33])[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 109534701-Hydroxycyclobutanecarboxylic acidHCID 178478710HCID 178478710, compound2×

Product 1

HCID 178523606HCID 178523606, compound

Procedure

The title compound, colorless semi-solid (73 mg, 69%), MS (ISP) m/z=427.4 [(M+H)+], was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 1-hydroxy-cyclobutane-carboxylic acid.

Sources & evidence

ORD record
ord-699407f4f5914ef8b6a10f2f9d68cc99
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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