4-(Piperidin-1-yl)benzoic acid → HCID 178523595, compound

HRID 331456Notes

Reaction equation

HRID 331456 reaction equation
Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[N:27]1([C:33]2[CH:41]=[CH:40][C:36]([C:37](O)=[O:38])=[CH:35][CH:34]=2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:37](=[O:38])[C:36]5[CH:40]=[CH:41][C:33]([N:27]6[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]6)=[CH:34][CH:35]=5)[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 7645994-(Piperidin-1-yl)benzoic acidHCID 178478710HCID 178478710, compound2×

Product 1

HCID 178523595HCID 178523595, compound

Procedure

The title compound, white solid (116 mg, 90%), MS (ISP) m/z=516.3 [(M+H)+], mp 248° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 4-piperidin-1-yl-benzoic acid.

Sources & evidence

ORD record
ord-ace013ccb0714eafb00f8df863afaab2
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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