HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluorocyclopropane-1-carboxylic acid → HCID 178523583, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluorocyclopropane-1-carboxylic acid | HCID 2782823 | — |
| Reactant | HCID 178478710 | HCID 178478710 | — |
| Product | HCID 178523583 | HCID 178523583 | — |
Reaction Steps
The title compound, light yellow solid (79 mg, 73%), MS (ISP) m/z=433.4 [(M+H)+], mp 199° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 2,2-difluoro-cyclopropane-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877778B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-457ae41239d143899024d45d8245dcee |
| Source note | uspto-grants-2014_11 |