Oxane-4-carboxylic acid → HCID 178523628, compound

HRID 331465Notes

Reaction equation

HRID 331465 reaction equation
Cl.Cl.[F:3][C:4]1[C:12]2[O:11][CH:10]=[CH:9][C:8]=2[C:7]([CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]3[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]3)[CH2:15][CH2:14]2)=[CH:6][CH:5]=1.[O:28]1[CH2:33][CH2:32][CH:31]([C:34](O)=[O:35])[CH2:30][CH2:29]1>>[F:3][C:4]1[C:12]2[O:11][CH:10]=[CH:9][C:8]=2[C:7]([CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]3[CH2:22][CH2:23][C@H:24]([NH:27][C:34]([CH:31]4[CH2:32][CH2:33][O:28][CH2:29][CH2:30]4)=[O:35])[CH2:25][CH2:26]3)[CH2:15][CH2:14]2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 219302Oxane-4-carboxylic acidHCID 178478711HCID 178478711, compound2×

Product 1

HCID 178523628HCID 178523628, compound

Procedure

The title compound, off-white solid (87 mg, 76%), MS (ISP) m/z=457.4 [(M+H)+], mp 208° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(7-fluoro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate C) (104 mg, 0.25 mmol) and tetrahydropyran-4-yl-carboxylic acid.

Sources & evidence

ORD record
ord-462602dc65e3432c9ae671aea2de02c6
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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