Oxane-4-carboxylic acid → HCID 178523628, compound

Participants

Reaction Steps

The title compound, off-white solid (87 mg, 76%), MS (ISP) m/z=457.4 [(M+H)+], mp 208° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(7-fluoro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate C) (104 mg, 0.25 mmol) and tetrahydropyran-4-yl-carboxylic acid.

Provenance & Evidence