3-Methoxypropionic acid → HCID 178495576, compound

HRID 331467Notes

Reaction equation

HRID 331467 reaction equation
Cl.Cl.[F:3][C:4]1[C:12]2[O:11][CH:10]=[CH:9][C:8]=2[C:7]([CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]3[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]3)[CH2:15][CH2:14]2)=[CH:6][CH:5]=1.[CH3:28][O:29][CH2:30][CH2:31][C:32](O)=[O:33]>>[F:3][C:4]1[C:12]2[O:11][CH:10]=[CH:9][C:8]=2[C:7]([CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]3[CH2:22][CH2:23][C@H:24]([NH:27][C:32](=[O:33])[CH2:31][CH2:30][O:29][CH3:28])[CH2:25][CH2:26]3)[CH2:15][CH2:14]2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 1344423-Methoxypropionic acidHCID 178478711HCID 178478711, compound2×

Product 1

HCID 178495576HCID 178495576, compound

Procedure

The title compound, white solid (60 mg, 56%), MS (ISP) m/z=431.5 [(M+H)+], mp 177° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(7-fluoro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate C) (104 mg, 0.25 mmol) and 3-methoxypropionic acid.

Sources & evidence

ORD record
ord-2e3535cdf2f34f2a9b2abe6d8b22fd68
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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