反应详情

A mixture of 8.1 mmol of 2-chloro-5-ethanesulfonyl-benzoxazole, 8.3 mmol piperazine-1-carboxylic acid tert-butyl ester and 9.8 mmol of potassium carbonate in 20 ml of acetonitrile was refluxed for 16 hours. The reaction mixture was cooled, concentrated in vacuo and treated with 50 ml water. Extraction with ethyl acetate and recrystallisation from a concentrated ethyl acetate solution yielded the title compound as a brownish solid.

1. temperaturewas refluxed for 16 hours
2. temperatureThe reaction mixture was cooled
3. concentrationconcentrated in vacuo
4. additiontreated with 50 ml water
5. extractionExtraction
6. customwith ethyl acetate and recrystallisation from a concentrated ethyl acetate solution