2-Isobutoxy-5-methanesulfonyl-benzoic acid → [4-(5-Ethanesulfonyl-benzoxazol-2-yl)-piperazin-1-yl]-(2-isobutoxy-5-methanesulfonyl-phenyl)-methanone

HRID 33149Notes

Reaction equation

HRID 33149 reaction equation
[CH2:1]([O:5][C:6]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=1[C:8]([OH:10])=O)[CH:2]([CH3:4])[CH3:3].Cl.[CH2:20]([S:22]([C:25]1[CH:26]=[CH:27][C:28]2[O:32][C:31]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)=[N:30][C:29]=2[CH:39]=1)(=[O:24])=[O:23])[CH3:21]>>[CH2:20]([S:22]([C:25]1[CH:26]=[CH:27][C:28]2[O:32][C:31]([N:33]3[CH2:34][CH2:35][N:36]([C:8]([C:7]4[CH:11]=[C:12]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:13]=[CH:14][C:6]=4[O:5][CH2:1][CH:2]([CH3:3])[CH3:4])=[O:10])[CH2:37][CH2:38]3)=[N:30][C:29]=2[CH:39]=1)(=[O:23])=[O:24])[CH3:21]

Participants

3

Reactant 2

HCID 235031102-Isobutoxy-5-methanesulfonyl-benzoic acidHCID 688960685-Ethanesulfonyl-2-piperazin-1-yl-benzoxazole hydrochloride

Product 1

HCID 58906319[4-(5-Ethanesulfonyl-benzoxazol-2-yl)-piperazin-1-yl]-(2-isobutoxy-5-methanesulfonyl-phenyl)-methanone

Procedure

Prepared in analogy to example 1.1 b) from 2-isobutoxy-5-methanesulfonyl-benzoic acid (Example 2.4) and 5-ethanesulfonyl-2-piperazin-1-yl-benzoxazole hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate) to yield the title compound as a colorless solid.

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate)

Sources & evidence

ORD record
ord-9098cd3818074b9d9d2ecb7c37892ce5
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

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