HRID331492

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1515244

4-Pyridin-3-yl-benzoic acid

C12H9NO2

结构：Cl.Cl.N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1

HCID178478710

未命名化合物

2 次

PRODUCTS

生成物

结构：O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1)c1ccc(-c2cccnc2)cc1

HCID178523588

未命名化合物

PROCEDURE

实验过程

The title compound, off-white solid (54 mg, 53%), MS (ISP) m/z=510.5 [(M+H)+], mp 224° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 4-pyridin-3-yl-benzoic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6cfdc9a36ddd4b2991cb3eef5c08203a
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08877778B2
来源说明: uspto-grants-2014_11

反应 SMILES

Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[N:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:41]=[CH:40][C:36]([C:37](O)=[O:38])=[CH:35][CH:34]=2)[CH:28]=1>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:37](=[O:38])[C:36]5[CH:35]=[CH:34][C:33]([C:29]6[CH:28]=[N:27][CH:32]=[CH:31][CH:30]=6)=[CH:41][CH:40]=5)[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1