2-Isopropoxy-5-methylsulfonylbenzoic acid → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(6-methoxy-benzothiazol-2-yl)-piperazin-1-yl]-methanone

HRID 33151Notes

Reaction equation

HRID 33151 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:34]=[CH:33][C:23]2[N:24]=[C:25]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[S:26][C:22]=2[CH:21]=1>O1CCCC1>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:30]1[CH2:31][CH2:32][N:27]([C:25]2[S:26][C:22]3[CH:21]=[C:20]([O:19][CH3:18])[CH:34]=[CH:33][C:23]=3[N:24]=2)[CH2:28][CH2:29]1)=[O:9])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acidHCID 220289286-Methoxy-2-(piperazin-1-yl)benzo[d]thiazole

Product 1

HCID 11598337(2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(6-methoxy-benzothiazol-2-yl)-piperazin-1-yl]-methanone

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in analogy to example 1.1 b) from 2-Isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 6-Methoxy-2-piperazin-1-yl-benzothiazole in tetrahydrofuran. The crude material was purified by chromatography (SiO2, heptane/ethyl acetate) to yield the title compound as a white foam.

Workup

  1. customThe crude material was purified by chromatography (SiO2, heptane/ethyl acetate)

Sources & evidence

ORD record
ord-8ffa461ef50948b8b22060f1549cfa11
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

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