2-Isopropoxy-5-methylsulfonylbenzoic acid → HCID 11526024, compound

HRID 33155Notes

Reaction equation

HRID 33155 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[CH3:19][O:20][C:21]1[C:26]2[N:27]=[C:28]([N:30]3[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]3)[S:29][C:25]=2[CH:24]=[CH:23][CH:22]=1>O1CCCC1>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:33]1[CH2:34][CH2:35][N:30]([C:28]2[S:29][C:25]3[CH:24]=[CH:23][CH:22]=[C:21]([O:20][CH3:19])[C:26]=3[N:27]=2)[CH2:31][CH2:32]1)=[O:9])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acidHCID 688956604-Methoxy-2-piperazin-1-yl-benzothiazole hydrochloride

Product 1

HCID 11526024HCID 11526024, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in analogy to example 1.1 b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 4-Methoxy-2-piperazin-1-yl-benzothiazole hydrochloride in tetrahydrofuran. The crude material was purified by chromatography (SiO2, heptane/ethyl acetate), and the residue was then triturated in ether to yield the title compound as a white solid.

Workup

  1. customThe crude material was purified by chromatography (SiO2, heptane/ethyl acetate)
  2. customthe residue was then triturated in ether

Sources & evidence

ORD record
ord-4f4b6e1542bb4f1cb3be6c76319ecead
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

Loading…