Hydrochloric Acid → HCID 44539321, compound

HRID 331662Notes

Reaction equation

HRID 331662 reaction equation
[O:1]=[C:2]1[CH:7]([N:8]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:17][NH:18][C:19](=[O:38])[NH:20][C:21]4[CH:22]=[C:23]5[C:28](=[CH:29][CH:30]=4)[CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]5)[CH:14]=3)[C:9]2=[O:39])[CH2:6][CH2:5][C:4](=[O:40])[NH:3]1.Cl>C(Cl)Cl.C(OCC)C>[O:1]=[C:2]1[CH:7]([N:8]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:17][NH:18][C:19]([NH:20][C:21]4[CH:22]=[C:23]5[C:28](=[CH:29][CH:30]=4)[CH2:27][NH:26][CH2:25][CH2:24]5)=[O:38])[CH:14]=3)[C:9]2=[O:39])[CH2:6][CH2:5][C:4](=[O:40])[NH:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 46199031HCID 46199031, compound

Product 1

HCID 44539321HCID 44539321, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A mixture of tert-butyl 6-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)ureido)-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.55 g, 1.0 mmol) in methylene chloride (100 mL) is treated with HCl (5 mL of a 2N solution in diethyl ether), and stirred at ambient temperature for 48 hours. The mixture is evaporated under vacuum, and triturated in ethyl acetate (10 mL), filtered, and dried under vacuum.

Workup

  1. customThe mixture is evaporated under vacuum
  2. customtriturated in ethyl acetate (10 mL)
  3. filtrationfiltered
  4. customdried under vacuum

Sources & evidence

ORD record
ord-77e4b333f4364d0e944f4ab96eeec37b
Source dataset
uspto-grants-2014_11
Patent number
US08877780B2

Reaction notes

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