反应详情

3-{1-[1-(4-Chlorophenyl)cyclobutyl]-2-nitroethyl}benzonitrile (3.0 g, 8.8 mmol) was dissolved in tetrahydrofuran (37 ml) and zinc dust (8.63 g, 132 mmol) was added followed by acetic acid (7.34 ml, 8.8 mmol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was filtered through celite and diluted with ethyl acetate. The solution was washed with aqueous sodium bicarbonate (two times), dried (magnesium sulfate) and concentrated in vacuo. Yield: 2.41 g (7.75 mmol, 88%)

1. filtrationThe reaction mixture was filtered through celite
2. additiondiluted with ethyl acetate
3. washThe solution was washed with aqueous sodium bicarbonate (two times)
4. dry with materialdried (magnesium sulfate)
5. concentrationconcentrated in vacuo