反应详情

A mixture of 9.1 mmol 2-chloroquinoxaline, 10.0 mmol piperazine-1-carboxylic acid tert-butyl ester, 22.8 mmol potassium carbonate and 2.1 mmol potassium iodide in 20 ml of toluene was refluxed overnight. The reaction mixture was cooled, poured into water and extracted 3 times with ethyl acetate. The organic phase was dried, evaporated and the title compound was crystallised from methanol. Yellowish solid.

1. temperaturewas refluxed overnight
2. temperatureThe reaction mixture was cooled
3. extractionextracted 3 times with ethyl acetate
4. customThe organic phase was dried
5. customevaporated
6. customthe title compound was crystallised from methanol