Hydrochloric Acid → 2-Piperazin-1-yl-quinoxaline hydrochloride

HRID 33175Notes

Reaction equation

HRID 33175 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[N:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[N:11]1([C:14]2[CH:23]=[N:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25070624tert-Butyl 4-(quinoxalin-2-yl)piperazine-1-carboxylate

Product 1

HCID 126864162-Piperazin-1-yl-quinoxaline hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared in analogy to example 1.6(d) from 4-quinoxalin-2-yl-piperazine-1-carboxylic acid tert.-butyl ester and dioxane saturated with gaseous hydrochloric acid.

Sources & evidence

ORD record
ord-7826b6795d924f95b2ab22a6afc42c5c
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

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