1-Aminocyclopropanecarbonitrile → HCID 57520474, 화합물

HRID 331957노트

반응식

HRID 331957 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=1.[NH2:24][C:25]1([C:28]#[N:29])[CH2:27][CH2:26]1>>[C:28]([C:25]1([NH:24][C:19](=[O:21])[C:18]2[CH:22]=[CH:23][C:15]([O:14][CH2:13][C:3]3[C:4]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:16][CH:17]=2)[CH2:27][CH2:26]1)#[N:29]

참가 물질

3

반응물 2

HCID 5568881-AminocyclopropanecarbonitrileHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

생성물 1

HCID 57520474HCID 57520474, 화합물수율 51%

실험 절차

As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 1-amino-1-cyclopropanecarbonitrile instead of 2-aminoethyl isopropylether, to the title compound (61 mg, 51%) which was obtained as a white solid. MS: m/e=375.2 [M+H]+.

출처 및 근거

ORD 기록
ord-e9560cb13e3b4ff08c023a65f903a948
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877782B2

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