1-Benzofuran-2-sulfonyl chloride → N-(5-chloro-2-{[2-(1H-pyrazol-4-yl)ethyl]thio}phenyl)-1-benzofuran-2-sulfonamide

HRID 332163Notes

Reaction equation

HRID 332163 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][S:8][C:9]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:10]=2[NH2:11])[CH:3]=[N:2]1.[O:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[C:18]1[S:26](Cl)(=[O:28])=[O:27]>N1C=CC=CC=1>[Cl:16][C:13]1[CH:14]=[CH:15][C:9]([S:8][CH2:7][CH2:6][C:4]2[CH:5]=[N:1][NH:2][CH:3]=2)=[C:10]([NH:11][S:26]([C:18]2[O:17][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH:19]=2)(=[O:27])=[O:28])[CH:12]=1

Participants

4

Reactant 2

HCID 27951721-Benzofuran-2-sulfonyl chlorideHCID 679728772-((2-(1H-pyrazol-4-yl)ethyl)thio)-5-chloroaniline

Product 1

HCID 67972412N-(5-chloro-2-{[2-(1H-pyrazol-4-yl)ethyl]thio}phenyl)-1-benzofuran-2-sulfonamideYield 45.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following General Procedure B, the title compound (123 mg) was prepared from 2-((2-(1H-pyrazol-4-yl)ethyl)thio)-5-chloroaniline (157 mg, 0.618 mmol) and benzofuran-2-sulfonyl chloride (133 mg, 0.618 mmol) in pyridine (3 ml).

Sources & evidence

ORD record
ord-11741cdc7a724b6a9187fa537fa4fa2e
Source dataset
uspto-grants-2014_11
Patent number
US08877804B2

Reaction notes

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