Hydrochloric Acid → HCID 18934738, compound

HRID 3322Notes

Reaction equation

HRID 3322 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]23[CH2:15][CH2:14][CH2:13][N:12]2[CH2:11][CH2:10][CH2:9]3)=[CH:4][CH:3]=1.[ClH:16]>CCOCC>[ClH:16].[ClH:16].[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]23[CH2:15][CH2:14][CH2:13][N:12]2[CH2:11][CH2:10][CH2:9]3)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18934739HCID 18934739, compound

Product 1

HCID 18934738HCID 18934738, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

7a-(6-methyl-3-pyridinyl)-hexahydro-1H-pyrrolizine (115 mg, 0.57 mmol) was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was crystallized from MeOH/Et2O and dried to afford the title compound as a free flowing white powder: mp 205°-208° C.; 1H NMR D2O, 300 MHz) δ2.14-2.49 (m, 6H), 2.57-2.66 (m, 5H), 3.34-3.42 (m, 2H), 3.78-3.87 (m, 2H), 7.56 (d, J=8.1 Hz, 1H), 8.05 (dd, J=8.1, 2.7 Hz, 1H), 8.61 (d, J=2.7 Hz, 1H); MS (CI/NH3) m/z: 203 (M+H)+ ; MS (CI/NH3): m/z 203 (M+H+); Anal. Calcd for C13H18N2.2 HCl.0.8 H2O: C, 53.91; H, 7.52; N, 9.67. Found: C, 53.80; H, 7.46; N, 9.68.

Workup

  1. customThe solvent was removed
  2. customthe solid was crystallized from MeOH/Et2O
  3. customdried

Sources & evidence

ORD record
ord-ea2e0597cfc34b5fb0309e1466c6a737
Source dataset
uspto-grants-1998_03
Patent number
US05733912

Reaction notes

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